09/15/2008 AT 1:45 PM ET
Christina Applegate has returned to work, her rep confirms to PEOPLE, as filming on her ABC comedy Samantha Who? resumed Monday in Los Angeles.
The actress underwent a double mastectomy in July, after being diagnosed with breast cancer. The surgery was a success, and Applegate, 36, says she’s cancer free.
Applegate subsequently appeared on the Sept. 5 Stand Up to Cancer telethon, and is expected to present at the Primetime Emmy Awards on Sept. 21. She is also nominated as lead actress in a comedy series.
Samantha Who?’s second season premieres on Oct. 13.
Reporting by JULIE JORDAN and LISA INGRASSIA