updated 11/22/2010 AT 12:00 PM ET
•originally published 11/22/2010 AT 1:50 PM ET
The actor, 39, spent the weekend partying in Miami with pal Jeff Beacher – and he Tweeted and posted photos of all the festivities.
The actor stayed at the Fontainebleau, where he hung out at LIV nightclub and Arkadia. On Friday, he took time out to get a tattoo of his grandfather on his right arm.
The next night, Arquette helped celebrate the two-year anniversary of LIV, where an onlooker says, “He was surrounded by women.”