updated 10/19/2011 AT 11:10 AM ET
•originally published 10/19/2011 AT 11:30 AM ET
Christina Applegate knows what Giuliana Rancic is going through, and says she’ll be there if the E! host – who has breast cancer – ever wants to talk.
“I know what that phone call sounds like and feels like,” Applegate, 39, herself a breast-cancer survivor, tells E! Online. “I hope she knows that I’m here if she wants to ever talk about it.”
Still, Applegate, who was declared cancer-free after a double mastectomy in 2008, realizes the sensitive nature of the topic, and wouldn’t presume to give unsolicited advice.